Disynaptic Inhibition between Neocortical Pyramidal Cells Mediated by Martinotti Cells

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Disynaptic Inhibition between Neocortical Pyramidal Cells Mediated by Martinotti Cells

Reliable activation of inhibitory pathways is essential for maintaining the balance between excitation and inhibition during cortical activity. Little is known, however, about the activation of these pathways at the level of the local neocortical microcircuit. We report a disynaptic inhibitory pathway among neocortical pyramidal cells (PCs). Inhibitory responses were evoked in layer 5 PCs follo...

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Disinhibition of cortical excitatory cell gate information flow through and between cortical columns. The major contribution of Martinotti cells (MC) is providing dendritic inhibition to excitatory neurons and therefore they are a main component of disinhibitory connections. Here we show by means of optogenetics that MC in layers II/III of the mouse primary somatosensory cortex are inhibited by...

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ژورنال

عنوان ژورنال: Neuron

سال: 2007

ISSN: 0896-6273

DOI: 10.1016/j.neuron.2007.02.012